M6PR (cation independent) ist ein Gen, das durch das Symbol IGF2R kodiert wird. Im Allgemeinen auch bezeichnet als: Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; IGF2R; MPRI. M6PR (cation independent) hat eine Masse von 274.38kDa und eine Aminosäurelänge von 2491.
Wir bieten 21 antikörper gegen M6PR (cation independent), aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Primaten.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Entrez Zusammenfassung
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).
Sequenzähnlichkeiten
Belongs to the MRL1/IGF2R family.
Zellort
Lysosome membrane.
Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
