LASP1 ist ein Gen, das durch das Symbol LASP1 kodiert wird. Im Allgemeinen auch bezeichnet als: LIM and SH3 domain protein 1; LASP-1; Metastatic lymph node gene 50 protein; MLN 50; MLN50. LASP1 hat eine Masse von 29.72kDa und eine Aminosäurelänge von 261.
Wir bieten 6 antikörper gegen LASP1, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
Entrez Zusammenfassung
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer.
Zellort
Cytoplasm > Cell cortex. Cytoplasm > Cytoskeleton.
Associated with the F-actin rich cortical cytoskeleton.
