Kallikrein 4 ist ein Gen, das durch das Symbol KLK4 kodiert wird. Im Allgemeinen auch bezeichnet als: Kallikrein-4; Enamel matrix serine proteinase 1; Kallikrein-like protein 1; KLK-L1; Prostase; Serine protease 17; KLK4; EMSP1; PRSS17; PSTS. Kallikrein 4 hat eine Masse von 27.03kDa, eine Aminosäurelänge von 254, und ist an Amelogenesis imperfecta, hypomaturation type, 2A1 beteiligt.
Wir bieten 7 antikörper gegen Kallikrein 4, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).
Entrez Zusammenfassung
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene.
Gewebespezifität
Expressed in prostate.
Rolle bei Krankheiten
Amelogenesis imperfecta, hypomaturation type, 2A1: A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.
Sequenzähnlichkeiten
Belongs to the peptidase S1 family. Kallikrein subfamily.
Posttranslationale Modifikation
N-glycosylated. The N-glycan structures are of complex diantennary or triantennary type, which may be further modified with up to 2 sialic acid residues.
