Kallikrein 11 ist ein Gen, das durch das Symbol KLK11 kodiert wird. Im Allgemeinen auch bezeichnet als: Kallikrein-11; hK11; Hippostasin; Serine protease 20; Trypsin-like protease; KLK11; PRSS20; TLSP. Kallikrein 11 hat eine Masse von 31.06kDa und eine Aminosäurelänge von 282.
Wir bieten 6 antikörper gegen Kallikrein 11, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Entrez Zusammenfassung
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed.
Gewebespezifität
Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
Sequenzähnlichkeiten
Belongs to the peptidase S1 family. Kallikrein subfamily.
Posttranslationale Modifikation
About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
