Junctional Adhesion Molecule 1 ist ein Gen, das durch das Symbol F11R kodiert wird. Im Allgemeinen auch bezeichnet als: Junctional adhesion molecule A; JAM-A; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; F11R; JAM1; JCAM. Junctional Adhesion Molecule 1 hat eine Masse von 32.58kDa und eine Aminosäurelänge von 299.
Wir bieten 8 antikörper gegen Junctional Adhesion Molecule 1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus, Ratte, Rind und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).
Entrez Zusammenfassung
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Gewebespezifität
Expressed in endothelium, epithelium and leukocytes (at protein level).
Sequenzähnlichkeiten
Belongs to the immunoglobulin superfamily.
Posttranslationale Modifikation
N-glycosylated.
Zellort
Cell junction > Tight junction. Cell membrane.
Localized at tight junctions of both epithelial and endothelial cells.
