JAK1 ist ein Gen, das durch das Symbol JAK1 kodiert wird. Im Allgemeinen auch bezeichnet als: Tyrosine-protein kinase Janus kinase 1; JAK-1AB. JAK1 hat eine Masse von 133.28kDa und eine Aminosäurelänge von 1154.
Wir bieten 14 antikörper gegen JAK1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952).
Entrez Zusammenfassung
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants.
Gewebespezifität
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Posttranslationale Modifikation
Autophosphorylated (PubMed:7615558). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558). Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529).
Zellort
Endomembrane system.
Wholly intracellular, possibly membrane associated.
