IRTA2 ist ein Gen, das durch das Symbol FCRL5 kodiert wird. Im Allgemeinen auch bezeichnet als: Fc receptor-like protein 5; FcR-like protein 5; BXMAS1; Fc receptor homolog 5; FcRH5; Immune receptor translocation-associated protein 2; FCRL5; FCRH5. IRTA2 hat eine Masse von 106.44kDa und eine Aminosäurelänge von 977.
Wir bieten 9 antikörper gegen IRTA2, aufgewachsen in Kaninchen und Human, welche geeignet sind für WB, ELISA and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.
Entrez Zusammenfassung
This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gewebespezifität
Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level).
