IRF2 ist ein Gen, das durch das Symbol IRF2 kodiert wird. Im Allgemeinen auch bezeichnet als: Interferon regulatory factor 2; IRF-2. IRF2 hat eine Masse von 39.35kDa und eine Aminosäurelänge von 349.
Wir bieten 8 antikörper gegen IRF2, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Entrez Zusammenfassung
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
Gewebespezifität
Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
Sequenzähnlichkeiten
Belongs to the IRF family.
Posttranslationale Modifikation
Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
