IRE1 ist ein Gen, das durch das Symbol ERN1 kodiert wird. Im Allgemeinen auch bezeichnet als: Serine/threonine-protein kinase/endoribonuclease Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p-alphaa; ERN1. IRE1 hat eine Masse von 109.74kDa und eine Aminosäurelänge von 977.
Wir bieten 15 antikörper gegen IRE1, aufgewachsen in Kaninchen, Ziege und Huhn, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262).
Gewebespezifität
Ubiquitously expressed. High levels observed in pancreatic tissue.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Posttranslationale Modifikation
Autophosphorylated following homodimerization. Autophosphorylation promotes activation of the endoribonuclease domain.
Zellort
Endoplasmic reticulum membrane.
