IRAKM ist ein Gen, das durch das Symbol IRAK3 kodiert wird. Im Allgemeinen auch bezeichnet als: Interleukin-1 receptor-associated kinase 3; IRAK-3; IL-1 receptor-associated kinase M; IRAK-M; IRAK3. IRAKM hat eine Masse von 67.77kDa, eine Aminosäurelänge von 596, und ist an Asthma-related traits 5 beteiligt.
Wir bieten 11 antikörper gegen IRAKM, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Entrez Zusammenfassung
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.
Gewebespezifität
Expressed predominantly in peripheral blood lymphocytes.
Rolle bei Krankheiten
Asthma-related traits 5: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
