Integrin alpha E ist ein Gen, das durch das Symbol ITGAE kodiert wird. Im Allgemeinen auch bezeichnet als: Integrin alpha-E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; ITGAE. Integrin alpha E hat eine Masse von 130.16kDa und eine Aminosäurelänge von 1179.
Wir bieten 21 antikörper gegen Integrin alpha E, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Primaten.
Gen- und Proteininformationen
UniProt Zusammenfassung
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
Entrez Zusammenfassung
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.
Gewebespezifität
Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
Sequenzähnlichkeiten
Belongs to the integrin alpha chain family.
