Influenza A Virus ist ein Gen, das durch das Symbol HA kodiert wird. Im Allgemeinen auch bezeichnet als: Hemagglutinin; HA. Influenza A Virus hat eine Masse von 63.35kDa und eine Aminosäurelänge von 565.
Wir bieten 6 antikörper gegen Influenza A Virus, aufgewachsen in Maus und Ziege, welche geeignet sind für WB, IHC and ELISA.
Gen- und Proteininformationen
UniProt Zusammenfassung
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Sequenzähnlichkeiten
Belongs to the influenza viruses hemagglutinin family.
Posttranslationale Modifikation
Palmitoylated.
Zellort
Virion membrane. Host apical cell membrane.
Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
