IL21 ist ein Gen, das durch das Symbol IL21 kodiert wird. Im Allgemeinen auch bezeichnet als: Interleukin-21; IL-21; Za11. IL21 hat eine Masse von 18.65kDa, eine Aminosäurelänge von 162, und ist an Immunodeficiency, common variable, 11 beteiligt.
Wir bieten 24 antikörper gegen IL21, aufgewachsen in Kaninchen, Maus, Ziege, Huhn und Human, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus, Ratte, Rind, Kaninchen, Schaf, Hund und Primaten.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Entrez Zusammenfassung
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gewebespezifität
Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.
Rolle bei Krankheiten
Immunodeficiency, common variable, 11: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Sequenzähnlichkeiten
Belongs to the IL-15/IL-21 family.
