IL2 Receptor beta ist ein Gen, das durch das Symbol IL2RB kodiert wird. Im Allgemeinen auch bezeichnet als: Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; High affinity IL-2 receptor subunit beta; Interleukin-15 receptor subunit beta; p70-75; p75; IL2RB; IL15RB. IL2 Receptor beta hat eine Masse von 61.12kDa, eine Aminosäurelänge von 551, und ist an Immunodeficiency 63 with lymphoproliferation and autoimmunity beteiligt.
Wir bieten 8 antikörper gegen IL2 Receptor beta, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185).
Entrez Zusammenfassung
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression.
Rolle bei Krankheiten
Immunodeficiency 63 with lymphoproliferation and autoimmunity: An autosomal recessive disorder characterized by immune dysregulation resulting in lymphoid proliferation, dermatitis, enteropathy, autoantibodies, hypergammaglobulinemia, and immunodeficiency with recurrent infections. Patients show increased susceptibility to viral infections, particularly cytomegalovirus disease.
Sequenzähnlichkeiten
Belongs to the type I cytokine receptor family. Type 4 subfamily.
