IL13 ist ein Gen, das durch das Symbol IL13 kodiert wird. Im Allgemeinen auch bezeichnet als: Interleukin-13; IL-13; NC30. IL13 hat eine Masse von 15.82kDa, eine Aminosäurelänge von 146, und ist an Allergic rhinitis beteiligt.
Wir bieten 38 antikörper gegen IL13, aufgewachsen in Kaninchen, Maus, Ziege, Ratte, Huhn und Human, welche geeignet sind für WB, IHC, ELISA and FC mit Proben abgeleitet von Human, Maus, Ratte, Rind, Schwein, Kaninchen, Schaf, Hund und Primaten.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).
Entrez Zusammenfassung
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Rolle bei Krankheiten
Allergic rhinitis: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
Sequenzähnlichkeiten
Belongs to the IL-4/IL-13 family.
