IL13 receptor alpha 1 ist ein Gen, das durch das Symbol IL13RA1 kodiert wird. Im Allgemeinen auch bezeichnet als: Interleukin-13 receptor subunit alpha-1; IL-13 receptor subunit alpha-1; Cancer/testis antigen 19; CT19; IL13RA1; IL13R; IL13RA. IL13 receptor alpha 1 hat eine Masse von 48.76kDa und eine Aminosäurelänge von 427.
Wir bieten 6 antikörper gegen IL13 receptor alpha 1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
Entrez Zusammenfassung
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
Gewebespezifität
Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
Sequenzähnlichkeiten
Belongs to the type I cytokine receptor family. Type 5 subfamily.
