IL1 alpha ist ein Gen, das durch das Symbol IL1A kodiert wird. Im Allgemeinen auch bezeichnet als: Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1; IL1A; IL1F1. IL1 alpha hat eine Masse von 30.61kDa und eine Aminosäurelänge von 271.
Wir bieten 26 antikörper gegen IL1 alpha, aufgewachsen in Kaninchen, Maus, Ziege und Human, welche geeignet sind für WB, IHC, ELISA and FC mit Proben abgeleitet von Human, Maus, Ratte, Rind, Schwein und Kaninchen.
Gen- und Proteininformationen
UniProt Zusammenfassung
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
Sequenzähnlichkeiten
Belongs to the IL-1 family.
Zellort
Secreted.
The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
