IKZF3 ist ein Gen, das durch das Symbol IKZF3 kodiert wird. Im Allgemeinen auch bezeichnet als: Zinc finger protein Aiolos; Ikaros family zinc finger protein 3; ZNFN1A3. IKZF3 hat eine Masse von 58.02kDa und eine Aminosäurelänge von 509.
Wir bieten 7 antikörper gegen IKZF3, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Entrez Zusammenfassung
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
Gewebespezifität
Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
Sequenzähnlichkeiten
Belongs to the Ikaros C2H2-type zinc-finger protein family.
Posttranslationale Modifikation
Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
Zellort
Nucleus. Cytoplasm.
