IKB beta ist ein Gen, das durch das Symbol NFKBIB kodiert wird. Im Allgemeinen auch bezeichnet als: NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IkB-B; Thyroid receptor-interacting protein 9; TR-interacting protein 9; NFKBIB; IKBB; TRIP9. IKB beta hat eine Masse von 37.77kDa und eine Aminosäurelänge von 356.
Wir bieten 7 antikörper gegen IKB beta, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Entrez Zusammenfassung
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.
Gewebespezifität
Expressed in all tissues examined.
Sequenzähnlichkeiten
Belongs to the NF-kappa-B inhibitor family.
Posttranslationale Modifikation
Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
Zellort
Cytoplasm. Nucleus.
