IgG4 ist ein Gen, das durch das Symbol IGHG4 kodiert wird. Im Allgemeinen auch bezeichnet als: Immunoglobulin heavy constant gamma 4; Ig gamma-4 chain C region; IGHG4. IgG4 hat eine Masse von 35.94kDa und eine Aminosäurelänge von 327.
Wir bieten 5 antikörper gegen IgG4, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human.
Gen- und Proteininformationen
UniProt Zusammenfassung
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Zellort
Secreted. Cell membrane.
