IGFBP3 ist ein Gen, das durch das Symbol IGFBP3 kodiert wird. Im Allgemeinen auch bezeichnet als: Insulin-like growth factor-binding protein 3; IBP-3; IBP3. IGFBP3 hat eine Masse von 31.67kDa und eine Aminosäurelänge von 291.
Wir bieten 15 antikörper gegen IGFBP3, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Entrez Zusammenfassung
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gewebespezifität
Expressed by most tissues. Present in plasma.
Posttranslationale Modifikation
Phosphorylated by FAM20C in the extracellular medium.
