ICAM3 ist ein Gen, das durch das Symbol ICAM3 kodiert wird. Im Allgemeinen auch bezeichnet als: Intercellular adhesion molecule 3; ICAM-3; CDw50; ICAM-R. ICAM3 hat eine Masse von 59.54kDa und eine Aminosäurelänge von 547.
Wir bieten 31 antikörper gegen ICAM3, aufgewachsen in Kaninchen, Maus und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human.
Gen- und Proteininformationen
UniProt Zusammenfassung
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Entrez Zusammenfassung
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gewebespezifität
Leukocytes.
Sequenzähnlichkeiten
Belongs to the immunoglobulin superfamily. ICAM family.
Posttranslationale Modifikation
Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
