Iba1 ist ein Gen, das durch das Symbol AIF1 kodiert wird. Im Allgemeinen auch bezeichnet als: Allograft inflammatory factor 1; AIF-1; Ionized calcium-binding adapter molecule 1; Protein G1; AIF1; G1. Iba1 hat eine Masse von 16.7kDa und eine Aminosäurelänge von 147.
Wir bieten 22 antikörper gegen Iba1, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Entrez Zusammenfassung
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain.
Gewebespezifität
Detected in T-lymphocytes and peripheral blood mononuclear cells.
Posttranslationale Modifikation
Phosphorylated on serine residues.
Zellort
Cytoplasm > Cytoskeleton. Cell projection > Ruffle membrane. Cell projection > Phagocytic cup.
Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
