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Anti-Hsp90 beta Antikörper

25 Products

Hsp90 beta ist ein Gen, das durch das Symbol HSP90AB1 kodiert wird. Im Allgemeinen auch bezeichnet als: Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP90AB1; HSP90B; HSPC2; HSPCB. Hsp90 beta hat eine Masse von 83.26kDa und eine Aminosäurelänge von 724.

Wir bieten 25 antikörper gegen Hsp90 beta, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Kaninchen, Affe, Huhn, Hund, Katze, Hamster und Pferd.

Gen- und Proteininformationen

UniProt Zusammenfassung
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone that is involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823).
Entrez Zusammenfassung
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes.
Sequenzähnlichkeiten
Belongs to the heat shock protein 90 family.
Posttranslationale Modifikation
Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).
Zellort
Cytoplasm. Melanosome. Nucleus. Secreted. Cell membrane.

Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673). Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762).
Western Blot - Anti-HSP90 beta Antibody [H9010] (A305130) - Antibodies.com
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Western Blot - Anti-Hsp90 beta Antibody (A307597) - Antibodies.com
(7)
Western Blot - Anti-HSP90B (phospho Ser254) Antibody (A0013) - Antibodies.com
(6)
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Western Blot - Anti-HSP90B Antibody (B0013) - Antibodies.com
(5)
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Western Blot - Anti-HSP90 beta Antibody (A304780) - Antibodies.com
(5)
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Western Blot - Anti-HSP90B (phospho Ser226) Antibody (A1210) - Antibodies.com
(3)
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Western Blot - Anti-HSP90B Antibody (B1210) - Antibodies.com
(3)
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Western Blot - Anti-HSP90 beta Antibody [Hyb-K3701] (A304736) - Antibodies.com
(3)
Western Blot - Anti-Hsp90 beta Antibody (A13109) - Antibodies.com
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Western Blot - Anti-Hsp90 beta Antibody (A93016) - Antibodies.com
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Immunohistochemistry - Anti-HSP90 beta Antibody [HSP90AB1/3954] (A248881) - Antibodies.com
(4)
Produkt anzeigenMonospezifischer Antikörper
Western Blot - Anti-HSP90 beta Antibody [MBH90B] (A86040) - Antibodies.com
Produkt anzeigen10µg Versuchsgrößen
Immunohistochemistry - Anti-HSP90 beta Antibody [HSP90AB1/3952] - BSA and Azide free (A252059) - Antibodies.com
(4)
Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-HSP90 beta Antibody [HSP90AB1/3954] - BSA and Azide free (A252061) - Antibodies.com
(4)
Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-HSP90 beta Antibody [HSP90AB1/3952] (A248879) - Antibodies.com
(4)
Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-HSP90 beta Antibody [HSP90AB1/3951] (A248878) - Antibodies.com
(3)
Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-HSP90 beta Antibody [HSP90AB1/3953] (A248880) - Antibodies.com
(3)
Produkt anzeigenMonospezifischer Antikörper
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Immunohistochemistry - Anti-HSP90 beta Antibody [HSP90AB1/3951] - BSA and Azide free (A252058) - Antibodies.com
(3)
Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-HSP90 beta Antibody [HSP90AB1/3953] - BSA and Azide free (A252060) - Antibodies.com
(3)
Produkt anzeigenMonospezifischer Antikörper

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