Hsp105 ist ein Gen, das durch das Symbol HSPH1 kodiert wird. Im Allgemeinen auch bezeichnet als: Heat shock protein 105 kDa; Antigen NY-CO-25; Heat shock 110 kDa protein; HSPH1; HSP110; KIAA0201. Hsp105 hat eine Masse von 96.87kDa und eine Aminosäurelänge von 858.
Wir bieten 6 antikörper gegen Hsp105, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).
Entrez Zusammenfassung
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers.
Gewebespezifität
Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.
Sequenzähnlichkeiten
Belongs to the heat shock protein 70 family.
Posttranslationale Modifikation
Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.
