HRH1 ist ein Gen, das durch das Symbol HRH1 kodiert wird. Im Allgemeinen auch bezeichnet als: Histamine H1 receptor; H1R. HRH1 hat eine Masse von 55.78kDa und eine Aminosäurelänge von 487.
Wir bieten 6 antikörper gegen HRH1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Entrez Zusammenfassung
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 1 family.
Posttranslationale Modifikation
Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.
