HPV16 L1 ist ein Gen, das durch das Symbol L1 kodiert wird. Im Allgemeinen auch bezeichnet als: Major capsid protein L1; L1. HPV16 L1 hat eine Masse von 56.28kDa und eine Aminosäurelänge von 505.
Wir bieten 12 antikörper gegen HPV16 L1, aufgewachsen in Kaninchen und Maus, welche geeignet sind für IHC and ICC/IF.
Gen- und Proteininformationen
UniProt Zusammenfassung
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
Sequenzähnlichkeiten
Belongs to the papillomaviridae L1 protein family.
Posttranslationale Modifikation
ISGylated by host HERC5, this results in dominant-negative effect on virus infectivity.
Zellort
Virion. Host nucleus.
