Hormone sensitive lipase ist ein Gen, das durch das Symbol LIPE kodiert wird. Im Allgemeinen auch bezeichnet als: Hormone-sensitive lipase; HSL; LIPE. Hormone sensitive lipase hat eine Masse von 116.6kDa, eine Aminosäurelänge von 1076, und ist an Lipodystrophy, familial partial, 6 beteiligt.
Wir bieten 12 antikörper gegen Hormone sensitive lipase, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Entrez Zusammenfassung
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.
Rolle bei Krankheiten
Lipodystrophy, familial partial, 6: A form of lipodystrophy characterized by abnormal subcutaneous fat distribution. Affected individuals have increased visceral fat, impaired lipolysis, dyslipidemia, hepatic steatosis, systemic insulin resistance, and diabetes. Some patients manifest muscular dystrophy.
Sequenzähnlichkeiten
Belongs to the 'GDXG' lipolytic enzyme family.
Posttranslationale Modifikation
Phosphorylation by AMPK may block translocation to lipid droplets.
Zellort
Cell membrane. Membrane > Caveola. Cytoplasm > Cytosol.
Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.
