HMGCR ist ein Gen, das durch das Symbol HMGCR kodiert wird. Im Allgemeinen auch bezeichnet als: 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase. HMGCR hat eine Masse von 97.48kDa und eine Aminosäurelänge von 888.
Wir bieten 8 antikörper gegen HMGCR, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Entrez Zusammenfassung
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Sequenzähnlichkeiten
Belongs to the HMG-CoA reductase family.
Posttranslationale Modifikation
N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.
Zellort
Endoplasmic reticulum membrane.
