Histone H2A ist ein Gen, das durch das Symbol H2AC4 kodiert wird. Im Allgemeinen auch bezeichnet als: Histone H2A type 1-B/E.2/a/m; H2AC4; H2AFM; HIST1H2AB. Histone H2A hat eine Masse von 14.14kDa und eine Aminosäurelänge von 130.
Wir bieten 16 antikörper gegen Histone H2A, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Entrez Zusammenfassung
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
Sequenzähnlichkeiten
Belongs to the histone H2A family.
Posttranslationale Modifikation
Deiminated on Arg-4 in granulocytes upon calcium entry.
Zellort
Nucleus. Chromosome.
