Hepatitis B Virus Surface Antigen ist ein Gen, das durch das Symbol S kodiert wird. Im Allgemeinen auch bezeichnet als: Large envelope protein; L glycoprotein; L-HBsAg; LHB; Large S protein; Large surface protein; Major surface antigen; S. Hepatitis B Virus Surface Antigen hat eine Masse von 42.35kDa und eine Aminosäurelänge von 389.
Wir bieten 9 antikörper gegen Hepatitis B Virus Surface Antigen, aufgewachsen in Kaninchen, Maus und Human, welche geeignet sind für IHC, ELISA and ICC/IF mit Proben abgeleitet von Human.
Gen- und Proteininformationen
UniProt Zusammenfassung
The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
Sequenzähnlichkeiten
Belongs to the orthohepadnavirus major surface antigen family.
Posttranslationale Modifikation
Isoform M is N-terminally acetylated by host at a ratio of 90%, and N-glycosylated by host at the pre-S2 region.
Biotechnologische Verwendung
Systematic vaccination of individuals at risk of exposure to the virus has been the main method of controlling the morbidity and mortality associated with hepatitis B. The first hepatitis B vaccine was manufactured by the purification and inactivation of HBsAg obtained from the plasma of chronic hepatitis B virus carriers. The vaccine is now produced by recombinant DNA techniques and expression of the S isoform in yeast cells. The pre-S region do not seem to induce strong enough antigenic response.
