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Anti-Haptoglobin Antikörper

37 Products

Haptoglobin ist ein Gen, das durch das Symbol HP kodiert wird. Im Allgemeinen auch bezeichnet als: Zonulin; HP. Haptoglobin hat eine Masse von 45.21kDa, eine Aminosäurelänge von 406, und ist an Anhaptoglobinemia beteiligt.

Wir bieten 37 antikörper gegen Haptoglobin, aufgewachsen in Kaninchen, Maus, Ziege, Human und Sheep, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP and ChIP mit Proben abgeleitet von Human, Maus, Ratte und Schwein.

Gen- und Proteininformationen

UniProt Zusammenfassung
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
Entrez Zusammenfassung
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Expressed by the liver and secreted in plasma.
Rolle bei Krankheiten
Anhaptoglobinemia: A condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Congenital haptoglobin deficiency is a risk factor for anaphylactic non-hemolytic transfusion reactions.
Sequenzähnlichkeiten
Belongs to the peptidase S1 family.
Zellort
Secreted.
Western Blot - Anti-Haptoglobin Antibody [ARC1298] (A305627) - Antibodies.com
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Western Blot - Anti-Haptoglobin Antibody (A13513) - Antibodies.com
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SDS-PAGE - Anti-Haptoglobin Antibody [Research Grade Biosimilar] - Low endotoxin, Azide free (A324050) - Antibodies.com
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Produkt anzeigenRekombinant Antikörper
Immunohistochemistry - Anti-Haptoglobin Antibody [HP/3835] - BSA and Azide free (A278234) - Antibodies.com
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Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-Haptoglobin Antibody [HP/3835] (A277646) - Antibodies.com
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Produkt anzeigenMonospezifischer Antikörper
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Immunofluorescence - Anti-Haptoglobin Antibody (A92029) - Antibodies.com
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Western Blot - Anti-Haptoglobin alpha Chain Antibody (A82846) - Antibodies.com
Immunohistochemistry - Anti-Haptoglobin Antibody [HP/3840] - BSA and Azide free (A278233) - Antibodies.com
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Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-Haptoglobin Antibody [HP/3837] - BSA and Azide free (A278235) - Antibodies.com
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Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-Haptoglobin Antibody [HP/3840] (A277645) - Antibodies.com
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Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-Haptoglobin Antibody [HP/3837] (A277647) - Antibodies.com
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Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-Haptoglobin Antibody [HP/3839] - BSA and Azide free (A278236) - Antibodies.com
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Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-Haptoglobin Antibody [HP/3839] (A277648) - Antibodies.com
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Produkt anzeigenMonospezifischer Antikörper
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Anti-Haptoglobin (V328) Antibody from Bioworld Technology (BS3681) - Antibodies.com
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Haptoglobin antibody from Signalway Antibody (23017) - Antibodies.com
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Haptoglobin antibody from Signalway Antibody (23016) - Antibodies.com
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Anti-Haptoglobin / HP Antibody from Bioworld Technology (BS6628) - Antibodies.com
Haptoglobin Polyclonal Antibody from Signalway Antibody (42609) - Antibodies.com
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