GSTM2 ist ein Gen, das durch das Symbol GSTM2 kodiert wird. Im Allgemeinen auch bezeichnet als: Glutathione S-transferase Mu 2; GST class-mu 2-2; GST4. GSTM2 hat eine Masse von 25.75kDa und eine Aminosäurelänge von 218.
Wir bieten 6 antikörper gegen GSTM2, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Entrez Zusammenfassung
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
Sequenzähnlichkeiten
Belongs to the GST superfamily. Mu family.
