GRK2 ist ein Gen, das durch das Symbol GRK2 kodiert wird. Im Allgemeinen auch bezeichnet als: Beta-adrenergic receptor kinase 1; Beta-ARK-1; G-protein coupled receptor kinase 2; ADRBK1; BARK; BARK1. GRK2 hat eine Masse von 79.57kDa und eine Aminosäurelänge von 689.
Wir bieten 19 antikörper gegen GRK2, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus, Ratte und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).
Entrez Zusammenfassung
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.
Gewebespezifität
Expressed in peripheral blood leukocytes.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Zellort
Cytoplasm. Cell membrane.
