GRK1 ist ein Gen, das durch das Symbol GRK1 kodiert wird. Im Allgemeinen auch bezeichnet als: Rhodopsin kinase RK; G protein-coupled receptor kinase 1; RHOK. GRK1 hat eine Masse von 63.53kDa, eine Aminosäurelänge von 563, und ist an Night blindness, congenital stationary, Oguchi type 2 beteiligt.
Wir bieten 11 antikörper gegen GRK1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).
Entrez Zusammenfassung
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation.
Gewebespezifität
Retinal-specific. Expressed in rods and cones cells.
Rolle bei Krankheiten
Night blindness, congenital stationary, Oguchi type 2: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Posttranslationale Modifikation
Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP.
Zellort
Membrane. Cell projection > Cilium > Photoreceptor outer segment.
Subcellular location is not affected by light or dark conditions.
