GRIK1 ist ein Gen, das durch das Symbol GRIK1 kodiert wird. Im Allgemeinen auch bezeichnet als: Glutamate receptor ionotropic, kainate 1; GluK1; Excitatory amino acid receptor 3; EAA3; Glutamate receptor 5; GluR-5; GLUR5. GRIK1 hat eine Masse von 103.98kDa und eine Aminosäurelänge von 918.
Wir bieten 9 antikörper gegen GRIK1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
Entrez Zusammenfassung
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
Gewebespezifität
Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
Sequenzähnlichkeiten
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
Zellort
Cell membrane. Cell junction > Synapse > Postsynaptic cell membrane.
