GPCR LGR6 ist ein Gen, das durch das Symbol LGR6 kodiert wird. Im Allgemeinen auch bezeichnet als: Leucine-rich repeat-containing G-protein coupled receptor 6; LGR6. GPCR LGR6 hat eine Masse von 104.3kDa und eine Aminosäurelänge von 967.
Wir bieten 8 antikörper gegen GPCR LGR6, aufgewachsen in Kaninchen, welche geeignet sind für WB, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.
Entrez Zusammenfassung
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 1 family.
