GPCR GPR75 ist ein Gen, das durch das Symbol GPR75 kodiert wird. Im Allgemeinen auch bezeichnet als: Probable G-protein coupled receptor 75; GPR75. GPCR GPR75 hat eine Masse von 59.36kDa und eine Aminosäurelänge von 540.
Wir bieten 14 antikörper gegen GPCR GPR75, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
Entrez Zusammenfassung
GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.
Gewebespezifität
Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 1 family.
