GPBB ist ein Gen, das durch das Symbol PYGB kodiert wird. Im Allgemeinen auch bezeichnet als: Glycogen phosphorylase, brain form; PYGB. GPBB hat eine Masse von 96.7kDa und eine Aminosäurelänge von 843.
Wir bieten 7 antikörper gegen GPBB, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228).
Entrez Zusammenfassung
The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.
Sequenzähnlichkeiten
Belongs to the glycogen phosphorylase family.
Posttranslationale Modifikation
Phosphorylated (PubMed:27402852). Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A (By similarity).
