GOLPH2 ist ein Gen, das durch das Symbol GOLM1 kodiert wird. Im Allgemeinen auch bezeichnet als: Golgi membrane protein 1; Golgi membrane protein GP73; Golgi phosphoprotein 2; GOLM1; C9orf155. GOLPH2 hat eine Masse von 45.33kDa und eine Aminosäurelänge von 401.
Wir bieten 10 antikörper gegen GOLPH2, aufgewachsen in Kaninchen, Maus, Ziege und Human, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus, Ratte und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Unknown. Cellular response protein to viral infection.
Entrez Zusammenfassung
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene.
Gewebespezifität
Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.
Sequenzähnlichkeiten
Belongs to the GOLM1/CASC4 family.
Posttranslationale Modifikation
Glycosylated.
Zellort
Golgi apparatus > cis-Golgi network membrane.
Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.
