Glycoprotein VI ist ein Gen, das durch das Symbol GP6 kodiert wird. Im Allgemeinen auch bezeichnet als: Platelet GPVI; Glycoprotein 6; GP6. Glycoprotein VI hat eine Masse von 36.87kDa, eine Aminosäurelänge von 339, und ist an Bleeding disorder, platelet-type 11 beteiligt.
Wir bieten 6 antikörper gegen Glycoprotein VI, aufgewachsen in Kaninchen und Human, welche geeignet sind für WB, IHC, ELISA and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Entrez Zusammenfassung
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gewebespezifität
Megakaryocytes and platelets.
Rolle bei Krankheiten
Bleeding disorder, platelet-type 11: A mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen.
Posttranslationale Modifikation
N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
