Glucagon Receptor ist ein Gen, das durch das Symbol GCGR kodiert wird. Im Allgemeinen auch bezeichnet als: GL-R; GCGR. Glucagon Receptor hat eine Masse von 54.01kDa und eine Aminosäurelänge von 477.
Wir bieten 7 antikörper gegen Glucagon Receptor, aufgewachsen in Kaninchen und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
Entrez Zusammenfassung
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 2 family.
Posttranslationale Modifikation
Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding.
Zellort
Cell membrane.
Is rapidly internalized after ligand-binding.
