GLS2 ist ein Gen, das durch das Symbol GLS2 kodiert wird. Im Allgemeinen auch bezeichnet als: Glutaminase liver isoform, mitochondrial; GLS; L-glutaminase; L-glutamine amidohydrolase; GA. GLS2 hat eine Masse von 66.32kDa und eine Aminosäurelänge von 602.
Wir bieten 2 antikörper gegen GLS2, aufgewachsen in Kaninchen, welche geeignet sind für WB and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
Entrez Zusammenfassung
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms.
Gewebespezifität
Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas.
Sequenzähnlichkeiten
Belongs to the glutaminase family.
