GLP1R ist ein Gen, das durch das Symbol GLP1R kodiert wird. Im Allgemeinen auch bezeichnet als: Glucagon-like peptide 1 receptor; GLP-1 receptor. GLP1R hat eine Masse von 53.03kDa und eine Aminosäurelänge von 463.
Wir bieten 8 antikörper gegen GLP1R, aufgewachsen in Kaninchen, Ziege und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus, Ratte und Schwein.
Gen- und Proteininformationen
UniProt Zusammenfassung
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
Entrez Zusammenfassung
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 2 family.
Posttranslationale Modifikation
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
