GDF 9 ist ein Gen, das durch das Symbol GDF9 kodiert wird. Im Allgemeinen auch bezeichnet als: Growth/differentiation factor 9; GDF-9; GDF9. GDF 9 hat eine Masse von 51.44kDa, eine Aminosäurelänge von 454, und ist an Premature ovarian failure 14 beteiligt.
Wir bieten 9 antikörper gegen GDF 9, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
Entrez Zusammenfassung
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expression of this gene may be associated with polycystic ovary syndrome and mutations in this gene may be more common in mothers of dizygotic twins.
Gewebespezifität
Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level).
Rolle bei Krankheiten
Premature ovarian failure 14: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Sequenzähnlichkeiten
Belongs to the TGF-beta family.
Posttranslationale Modifikation
Phosphorylated; phosphorylation is critical for GDF9 function. In vitro, can be phosphorylated by CK at Ser-325.
