GCSF Receptor ist ein Gen, das durch das Symbol CSF3R kodiert wird. Im Allgemeinen auch bezeichnet als: Granulocyte colony-stimulating factor receptor; G-CSF receptor; CSF3R; GCSFR. GCSF Receptor hat eine Masse von 92.16kDa, eine Aminosäurelänge von 836, und ist an folgenden Krankheiten beteiligt: Hereditary neutrophilia; Neutropenia, severe congenital 7, autosomal recessive.
Wir bieten 15 antikörper gegen GCSF Receptor, aufgewachsen in Kaninchen, Maus, Ziege und Human, welche geeignet sind für WB, IHC, ELISA and FC mit Proben abgeleitet von Human und Maus.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.
Entrez Zusammenfassung
The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.
Gewebespezifität
One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta.
Rolle bei Krankheiten
Hereditary neutrophilia: A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood.
Neutropenia, severe congenital 7, autosomal recessive: A form of severe congenital neutropenia, a disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.
Sequenzähnlichkeiten
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Posttranslationale Modifikation
N-glycosylated.
