GCET2 ist ein Gen, das durch das Symbol GCSAM kodiert wird. Im Allgemeinen auch bezeichnet als: Germinal center-associated signaling and motility protein; Germinal center B-cell-expressed transcript 2 protein; Germinal center-associated lymphoma protein; hGAL; GCSAM; GAL. GCET2 hat eine Masse von 21.01kDa und eine Aminosäurelänge von 178.
Wir bieten 10 antikörper gegen GCET2, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB and IHC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
Entrez Zusammenfassung
This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gewebespezifität
Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen.
Posttranslationale Modifikation
Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN.
Zellort
Cytoplasm. Cell membrane.
It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
