GBP1 ist ein Gen, das durch das Symbol GBP1 kodiert wird. Im Allgemeinen auch bezeichnet als: Guanylate-binding protein 1; GTP-binding protein 1; GBP-1; Guanine nucleotide-binding protein 1; Interferon-induced guanylate-binding protein 1. GBP1 hat eine Masse von 67.93kDa und eine Aminosäurelänge von 592.
Wir bieten 13 antikörper gegen GBP1, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
Entrez Zusammenfassung
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.
Sequenzähnlichkeiten
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Posttranslationale Modifikation
Isoprenylation is required for proper subcellular location.
Zellort
Cytoplasm. Golgi apparatus membrane. Cell membrane. Secreted.
Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.
