Gastric Inhibitory Polypeptide Receptor ist ein Gen, das durch das Symbol GIPR kodiert wird. Im Allgemeinen auch bezeichnet als: GIP-R; Glucose-dependent insulinotropic polypeptide receptor; GIPR. Gastric Inhibitory Polypeptide Receptor hat eine Masse von 53.16kDa und eine Aminosäurelänge von 466.
Wir bieten 6 antikörper gegen Gastric Inhibitory Polypeptide Receptor, aufgewachsen in Kaninchen und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Entrez Zusammenfassung
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 2 family.
Posttranslationale Modifikation
N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
