GAP43 ist ein Gen, das durch das Symbol GAP43 kodiert wird. Im Allgemeinen auch bezeichnet als: Neuromodulin; Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46. GAP43 hat eine Masse von 24.8kDa und eine Aminosäurelänge von 238.
Wir bieten 19 antikörper gegen GAP43, aufgewachsen in Kaninchen, Maus und Huhn, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Schwein, Affe, Huhn, Hund, Katze, Pferd, Xenopus und Zebrafisch.
Gen- und Proteininformationen
UniProt Zusammenfassung
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Entrez Zusammenfassung
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Sequenzähnlichkeiten
Belongs to the neuromodulin family.
Posttranslationale Modifikation
Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
Zellort
Cell membrane. Cell projection > Growth cone membrane. Cell junction > Synapse. Cell projection > Filopodium membrane. Perikaryon. Cell projection > Dendrite. Cell projection > Axon. Cytoplasm.
Cytoplasmic surface of growth cone and synaptic plasma membranes.
